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Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans
- Source :
- British Journal of Nutrition. 115:251-261
- Publication Year :
- 2015
- Publisher :
- Cambridge University Press (CUP), 2015.
-
Abstract
- Numerous studies have examined relationships between disease biomarkers (such as blood lipids) and levels of circulating or cellular fatty acids. In such association studies, fatty acids have typically been expressed as the percentage of a particular fatty acid relative to the total fatty acids in a sample. Using two human cohorts, this study examined relationships between blood lipids (TAG, and LDL, HDL or total cholesterol) and circulating fatty acids expressed either as a percentage of total or as concentration in serum. The direction of the correlation between stearic acid, linoleic acid, dihomo-γ-linolenic acid, arachidonic acid and DHA and circulating TAG reversed when fatty acids were expressed as concentrationsv. a percentage of total. Similar reversals were observed for these fatty acids when examining their associations with the ratio of total cholesterol:HDL-cholesterol. This reversal pattern was replicated in serum samples from both human cohorts. The correlations between blood lipids and fatty acids expressed as a percentage of total could be mathematically modelled from the concentration data. These data reveal that the different methods of expressing fatty acids lead to dissimilar correlations between blood lipids and certain fatty acids. This study raises important questions about how such reversals in association patterns impact the interpretation of numerous association studies evaluating fatty acids and their relationships with disease biomarkers or risk.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Linoleic acid
Medicine (miscellaneous)
Blood lipids
Biology
White People
Body Mass Index
Linoleic Acid
03 medical and health sciences
chemistry.chemical_compound
Risk Factors
Internal medicine
medicine
Humans
Triglycerides
Aged
chemistry.chemical_classification
Arachidonic Acid
030109 nutrition & dietetics
Nutrition and Dietetics
Cholesterol
Cholesterol, HDL
Fatty Acids
Fatty acid
Cholesterol, LDL
Middle Aged
Overweight
Lipids
United States
Black or African American
Oleic acid
Endocrinology
chemistry
Biochemistry
Female
lipids (amino acids, peptides, and proteins)
Arachidonic acid
Stearic acid
Biomarkers
Stearic Acids
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....871f1765c49eadd0242e96023beb6c0e