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Production of a Novel Viral Suppressive Activity Associated with Resistance to Infection among Female Sex Workers Exposed to HIV Type 1
- Source :
- AIDS Research and Human Retroviruses. 17:735-744
- Publication Year :
- 2001
- Publisher :
- Mary Ann Liebert Inc, 2001.
-
Abstract
- To investigate mechanisms of natural resistance to human immunodeficiency virus type 1 (HIV-1), we obtained blood samples from eight women who remained HIV-1 negative after3 years of high-risk sex work in Chiang Rai, Thailand. CD4+ T lymphocytes from these highly exposed, persistently seronegative (HEPS) women were readily infectable in vitro with HIV-1 subtypes B and E. Autologous CD8+ cell suppression of both HIV-1 subtypes was evident in HEPS infection cultures, but to an extent also observed in cultures from non-HIV-exposed individuals. Furthermore, production of beta-chemokines was not enhanced in HEPS cultures. However, HEPS cultures displayed significantly enhanced production of a soluble activity that suppressed postintegrated HIV-1 replication. This activity was the unique product of CD4+ T cell and monocyte cocultures. Therefore, although HEPS individuals are apparently susceptible to infection, the production of a postintegrated HIV-1 suppressive activity during monocyte-T cell interactions might protect against the establishment of infection by limiting viral dissemination.
- Subjects :
- CD4-Positive T-Lymphocytes
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
CD8-Positive T-Lymphocytes
Biology
Virus Replication
medicine.disease_cause
Monocytes
Virus
Cohort Studies
Acquired immunodeficiency syndrome (AIDS)
HIV Seronegativity
Virology
Immunopathology
medicine
Humans
Prospective Studies
Sida
Cells, Cultured
Immunity, Cellular
Monocyte
virus diseases
Thailand
biology.organism_classification
medicine.disease
Sex Work
Coculture Techniques
Infectious Diseases
medicine.anatomical_structure
Chemokines, CC
Culture Media, Conditioned
Lentivirus
HIV-1
Female
Viral disease
Subjects
Details
- ISSN :
- 19318405 and 08892229
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- AIDS Research and Human Retroviruses
- Accession number :
- edsair.doi.dedup.....871a3435b4d67ee9fe95b74bf9ca8339