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Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome
- Source :
- Kidney International Reports, Kidney International Reports, 2021, 6 (12), pp.3045-3053. ⟨10.1016/j.ekir.2021.09.017⟩
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- International audience; Introduction: Tubulointerstitial nephritis (TIN) and uveitis (TINU) syndrome is a rare disease. The renal prognosis is generally thought to be better in children with TINU syndrome than in adults. However, data are scarce. We aimed to investigate the long-term renal prognosis in a French cohort of children with TINU syndrome.Methods: We performed a national retrospective study including 23 French pediatric nephrology centers enrolling patients with TINU syndrome diagnosed between January 2000 and December 2018.Results: A total of 46 patients were included (52% female, median age 13.8 years). At diagnosis of TIN, the median estimated glomerular filtration rate (eGFR) was 30.6 ml/min per 1.73 m2 (4.9-62.8). The median time between diagnosis of uveitis and TIN was 0.4 months (-4.1; +17.1). All patients had anterior uveitis, but 12 (29%) were asymptomatic. Nearly all patients (44 of 46) received steroid treatment, and 12 patients (26%) received a second-line therapy. At last follow-up (median 2.8 years), the median eGFR was 87.5 ml/min per 1.73 m2 (60.3-152.7) and
- Subjects :
- Pediatrics
medicine.medical_specialty
Tubulointerstitial nephritis and uveitis
Renal function
tubulointerstitial nephritis and uveitis syndrome
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
Asymptomatic
Dobrin’s syndrome
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Clinical Research
medicine
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
business.industry
Retrospective cohort study
chronic kidney failure
medicine.disease
[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
pediatric
Nephrology
Dobrin's syndrome
Cohort
outcome
medicine.symptom
business
Uveitis
Kidney disease
Rare disease
Subjects
Details
- ISSN :
- 24680249
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Kidney International Reports
- Accession number :
- edsair.doi.dedup.....8715627e2c717d2a036f654d5b0c76d4