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Schistosoma mansoni: structural damage after treatment with oxamniquine
- Source :
- Memórias do Instituto Oswaldo Cruz, Volume: 82 Supplement 4, Pages: 347-352, Published: 1987, Memórias do Instituto Oswaldo Cruz., Vol 82, Pp 347-352 (1987)
- Publication Year :
- 1987
- Publisher :
- Instituto Oswaldo Cruz, Ministério da Saúde, 1987.
-
Abstract
- The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
- Subjects :
- Microbiology (medical)
Male
Pathology
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
lcsh:QR1-502
Peripheral blood mononuclear cell
lcsh:Microbiology
law.invention
Mice
Immune system
law
medicine
Animals
biology
Host (biology)
Nitroquinolines
Viral tegument
Schistosoma mansoni
biology.organism_classification
Oxamniquine
Microscopy, Electron
Microscopy, Electron, Scanning
Electron microscope
After treatment
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Memórias do Instituto Oswaldo Cruz, Volume: 82 Supplement 4, Pages: 347-352, Published: 1987, Memórias do Instituto Oswaldo Cruz., Vol 82, Pp 347-352 (1987)
- Accession number :
- edsair.doi.dedup.....870d8a8d62c9132d85eb40befefc4613