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Peroxidasins: novel players in tissue genesis

Authors :
Zalán Péterfi
Miklós Geiszt
Source :
Trends in Biochemical Sciences. 39:305-307
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.

Details

ISSN :
09680004
Volume :
39
Database :
OpenAIRE
Journal :
Trends in Biochemical Sciences
Accession number :
edsair.doi.dedup.....870839af11f459c6cabbd906c7bf7c57
Full Text :
https://doi.org/10.1016/j.tibs.2014.05.005