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Peroxidasins: novel players in tissue genesis
- Source :
- Trends in Biochemical Sciences. 39:305-307
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.
- Subjects :
- Collagen Type IV
Extracellular Matrix Proteins
Sulfur Compounds
technology, industry, and agriculture
macromolecular substances
Sulfilimine
Biology
Biochemistry
Basement Membrane
Extracellular matrix
chemistry.chemical_compound
Multicellular organism
Peroxidasin
Cross-Linking Reagents
Membrane
chemistry
Biophysics
Animals
Humans
Molecular Biology
Biogenesis
Protein crosslinking
Support matrix
Peroxidase
Subjects
Details
- ISSN :
- 09680004
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Trends in Biochemical Sciences
- Accession number :
- edsair.doi.dedup.....870839af11f459c6cabbd906c7bf7c57
- Full Text :
- https://doi.org/10.1016/j.tibs.2014.05.005