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In vivo anti-inflammatory and antinociceptive effects, and in vitro antioxidant, antiglycant and anti-neuroinflammatory actions of Syzygium malaccense
- Source :
- Anais da Academia Brasileira de Ciências v.93 suppl.4 2021, Anais da Academia Brasileira de Ciências, Academia Brasileira de Ciências (ABC), instacron:ABC, Anais da Academia Brasileira de Ciências, Volume: 93 Supplement 4, Article number: e20210457, Published: 26 NOV 2021, Anais da Academia Brasileira de Ciências, Vol 93, Iss suppl 4 (2021)
- Publication Year :
- 2021
- Publisher :
- Academia Brasileira de Ciências, 2021.
-
Abstract
- Syzygium malaccense is popularly used to treat inflammation and pain-related ailments. The species was assessed regarding its antioxidant, antiglycant, anti-inflammatory, including anti-neuroinflammatory, and antinociceptive activities. Different models were employed to measure S. malaccense extract (ESM) antioxidant activity. The antiglycant activity was determined using the glucose-induced protein glycation model. LPS-induced neuroinflammation on murine BV-2 microglial cell line was used for anti-neuroinflammatory activity evaluation. The croton oil-induced ear edema test was accomplished to evaluate the in vivo anti-inflammatory activity. Acetic acid-induced writhing together with formalin-induced paw licking assays were performed to evaluate the antinociceptive potential. Finally, the chemical characterization was accomplished by a UHPLC-MS analysis. ESM presented relevant antioxidant and antiglycant activity. NO production by BV-2 cells was reduced, indicating the relevant neuroprotective activity. ESM significantly decreased the mice ear edema induced by croton oil and the nociceptive stimulus induced by acetic acid and formalin by central and peripheral mechanisms. The flavonoids myricitrin, myricetin and quercetin were identified and, as far as we know, the alkaloid reserpine was reported in the species for the first time. The antioxidant and antiglycant potential of ESM, may be related to the in vivo anti-inflammatory and antinociceptive effects, and to the in vitro neuroinflammation inhibition.
- Subjects :
- Antioxidant
antioxidant
medicine.drug_class
Science
Syzygium
medicine.medical_treatment
Anti-Inflammatory Agents
Pharmacology
Antioxidants
Anti-inflammatory
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
In vivo
Antiglycant
medicine
Animals
Edema
oxidative stress
Croton oil
pain
Neuroinflammation
030304 developmental biology
Analgesics
0303 health sciences
Multidisciplinary
Plant Extracts
chemistry
inflammation
Myricetin
Quercetin
Myricitrin
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Anais da Academia Brasileira de Ciências v.93 suppl.4 2021, Anais da Academia Brasileira de Ciências, Academia Brasileira de Ciências (ABC), instacron:ABC, Anais da Academia Brasileira de Ciências, Volume: 93 Supplement 4, Article number: e20210457, Published: 26 NOV 2021, Anais da Academia Brasileira de Ciências, Vol 93, Iss suppl 4 (2021)
- Accession number :
- edsair.doi.dedup.....87017fa6dd51160990ab4642acebbbbc