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Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts
- Source :
- Heart Rhythm. 14:1675-1684
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Although time–domain measures of heart rate variability (HRV) are used to estimate cardiac autonomic tone and disease risk in multiethnic populations, the genetic epidemiology of HRV in Hispanics/Latinos has not been characterized. Objective The purpose of this study was to conduct a genome-wide association study of heart rate (HR) and its variability in the Hispanic Community Health Study/Study of Latinos, Multi-Ethnic Study of Atherosclerosis, and Women's Health Initiative Hispanic SNP-Health Association Resource project (n = 13,767). Methods We estimated HR (bpm), standard deviation of normal-to-normal interbeat intervals (SDNN, ms), and root mean squared difference in successive, normal-to-normal interbeat intervals (RMSSD, ms) from resting, standard 12-lead ECGs. We estimated associations between each phenotype and 17 million genotyped or imputed single nucleotide polymorphisms (SNPs), accounting for relatedness and adjusting for age, sex, study site, and ancestry. Cohort-specific estimates were combined using fixed-effects, inverse-variance meta-analysis. We investigated replication for select SNPs exceeding genome-wide (P Results Two genome-wide significant SNPs replicated in a European ancestry cohort, 1 one for RMSSD (rs4963772; chromosome 12) and another for SDNN (rs12982903; chromosome 19). A suggestive SNP for HR (rs236352; chromosome 6) replicated in an African-American cohort. Functional annotation of replicated SNPs in cardiac and neuronal tissues identified potentially causal variants and mechanisms. Conclusion This first genome-wide association study of HRV and HR in Hispanics/Latinos underscores the potential for even modestly sized samples of non-European ancestry to inform the genetic epidemiology of complex traits.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Genotype
Myocardial Infarction
Action Potentials
Single-nucleotide polymorphism
Genome-wide association study
Autonomic Nervous System
Bioinformatics
Polymorphism, Single Nucleotide
Article
Electrocardiography
03 medical and health sciences
Heart Rate
Physiology (medical)
Epidemiology
Diabetes Mellitus
Humans
Heart rate variability
Medicine
SNP
Chromosome 12
business.industry
Arrhythmias, Cardiac
Hispanic or Latino
United States
Black or African American
Phenotype
030104 developmental biology
Genetic epidemiology
Cohort
Calcium
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Genome-Wide Association Study
Demography
Subjects
Details
- ISSN :
- 15475271 and 12982903
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Heart Rhythm
- Accession number :
- edsair.doi.dedup.....8700a67cbdd7b08760d4867a320b1977