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Associations of cytosine deaminase gene polymorphisms with effectiveness of gemcitabine/cisplatin chemotherapy in patients of Xinjiang Uyghur and Han nationality with non-small cell lung cancer
- Source :
- The International Journal of Biological Markers. 34:389-397
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Background: Cytidine deaminase (CDA) polymorphisms may affect the response to gemcitabine/cisplatin chemotherapy in patients with non-small cell lung cancer (NSCLC). This study is designed to investigate the associations of CDA-79A>C and 208G>A polymorphisms and gemcitabine/cisplatin chemotherapy effectiveness in Xinjiang Uyghur and Han patients. Methods: This prospective cohort study enrolled consecutive patients with stage IIIb/IV NSCLC administered gemcitabine/cisplatin chemotherapy at the First Affiliated Hospital, Medical College of Shihezi University and the First People’s Hospital, Kashgar Region. CDA-A79C and CDA-G208A polymorphisms were detected by direct sequencing. Progression-free survival was analyzed by the Kaplan-Meier method. Associations of A79C and G208A polymorphisms with treatment effectiveness and progression-free survival were analyzed using logistic regression and multivariate Cox regression analyses. Subgroup analyses based on ethnicity were performed. Results: The study enrolled 120 patients. A79C and G208A polymorphisms followed the Hardy-Weinberg equilibrium. The frequencies of the AA, AC, and CC genotypes and the A and C alleles of A79C were 52.2%, 29.9%, 17.9%, 67.2%, and 32.8%, respectively, in Han patients and 75.4%, 18.9%, 5.7%, 84.9%, and 5.1%, respectively, in Uyghur patients. Uyghur patients had lower frequencies of A79C-AC/CC genotypes, A79C-C allele, G208A-GA genotype, and G208A-A allele ( PConclusion: For Uyghur and Han ethnic groups, A79C and G208A polymorphisms can be used as a promising biomarker for the chemotherapy efficacy and prognosis of NSCLC.
- Subjects :
- Adult
Male
0301 basic medicine
Antimetabolites, Antineoplastic
China
Cancer Research
Lung Neoplasms
medicine.medical_treatment
Clinical Biochemistry
Deoxycytidine
Pathology and Forensic Medicine
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Cytidine Deaminase
medicine
Humans
Prospective Studies
Progression-free survival
Lung cancer
Gene
Aged
Cisplatin
Chemotherapy
Polymorphism, Genetic
business.industry
Cytosine deaminase
Cytidine deaminase
Middle Aged
medicine.disease
Gemcitabine
Progression-Free Survival
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer research
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 17246008
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The International Journal of Biological Markers
- Accession number :
- edsair.doi.dedup.....86f5369dba63d94b80719d555230e583