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Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus
- Source :
- Lupus. 30(12)
- Publication Year :
- 2021
-
Abstract
- The neonatal Fc receptor (FcRn) is a ubiquitously expressed protein historically involved in IgG and albumin recycling. Recent data suggest an involvement in the pathophysiology of antibody-mediated autoimmune diseases. Among them, systemic lupus erythematosus (SLE) implies clinical and biological abnormalities of innate and adaptive circulating immune cells, potentially involving newly described functions of FcRn. In this study, FcRn expression was assessed by flow cytometry in peripheral blood leukocytes of 41 SLE patients with either active or inactive disease and 32 healthy donors. FcRn expression in B cells, natural killer cells, and T cells of SLE patients was statistically lower as compared to healthy donors. Conversely, FcRn level was statistically higher in non-classical monocyte subpopulations (CD14+CD16+ monocytes) of SLE patients versus healthy donors providing an interesting perspective to further explore its role in SLE pathophysiology.
- Subjects :
- Adult
Male
Adolescent
Lupus nephritis
Receptors, Fc
Monocytes
Young Adult
Neonatal Fc receptor
Rheumatology
immune system diseases
Medicine
Humans
Lupus Erythematosus, Systemic
skin and connective tissue diseases
Child
Aged
business.industry
Histocompatibility Antigens Class I
Receptors, IgG
Albumin
Middle Aged
medicine.disease
Pathophysiology
Case-Control Studies
Myeloid cells
Immunology
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 14770962
- Volume :
- 30
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Lupus
- Accession number :
- edsair.doi.dedup.....86efb994992dbcc0f07985a758193476