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Influence of ScaI and Natriuretic Peptide (NP) Clearance Receptor Polymorphisms of the NP System on NP Concentration in Chronic Heart Failure
- Source :
- Clinical Chemistry. 53:1886-1890
- Publication Year :
- 2007
- Publisher :
- Oxford University Press (OUP), 2007.
-
Abstract
- Background: Genetic variants related to the natriuretic peptide (NP) system [ScaI mutated allele (A1) of the atrial NP (ANP) gene and the C variant of the natriuretic peptide clearance receptor (NPRC) gene] have been identified as independent risk factors for cardiovascular morbidity and mortality. Despite the importance of NPs in heart failure (HF), the role of these polymorphisms in HF has not been evaluated.Methods: We screened 124 HF patients [mean (SD), age 66 (12) years, 100 men, ejection fraction 32% (10%), New York Heart Association (NYHA) class I–II 65, III–IV 59] for NP concentrations [ANP, brain NP (BNP) and amino-terminal pro-BNP (NT-proBNP)] and for the ScaI and NPRC variants.Results: ScaI polymorphism had no effect on NP concentration in the NYHA I–II subgroup. Conversely, in severe HF, A1 carriers had higher ANP (P ≤0.05), BNP (P Conclusions: The ScaI polymorphism of the ANP gene might be an important additive genetic factor influencing neurohormonal activation and disease progression in severe HF. The NPRC polymorphism is not an independent determinant of NP concentration in HF.
- Subjects :
- Male
medicine.medical_specialty
Heart disease
medicine.drug_class
Clinical Biochemistry
Biology
Atrial natriuretic peptide
Polymorphism (computer science)
Internal medicine
Natriuretic Peptide, Brain
Genotype
medicine
Natriuretic peptide
Humans
Allele
Aged
Heart Failure
Polymorphism, Genetic
Ejection fraction
Biochemistry (medical)
medicine.disease
Peptide Fragments
Endocrinology
Heart failure
Mutation
Female
Receptors, Atrial Natriuretic Factor
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15308561 and 00099147
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry
- Accession number :
- edsair.doi.dedup.....86e5fd4d2915b35725ff15648a3984cf