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High spectral and spatial resolution MRI of prostate cancer: a pilot study
- Source :
- Magn Reson Med
- Publication Year :
- 2021
-
Abstract
- Purpose High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water and fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility and potential utility of HiSS MRI for the diagnosis of prostate cancer. Methods HiSS MRI was acquired at 3 T from six patients who underwent prostatectomy, yielding a train of 127 phase-coherent gradient echo (GRE) images. In the temporal domain, changes in voxel intensity were analyzed and linear (R) and quadratic (R1, R2) quantifiers of signal logarithm decay were calculated. In the spectral domain, three signal scaling-independent parameters were calculated: water resonance peak width (PW), relative peak asymmetry (PRA), and relative peak distortion from ideal Lorentzian shape (PRD). Seven cancer and five normal tissue regions of interest were identified in correlation with pathology and compared. Results HiSS-derived quantifiers, except R2, showed high reproducibility (coefficients of variation, 5%-14%). Spectral domain quantifiers performed better than temporal domain quantifiers, with receiver operator characteristic areas under the curve ranging from of 0.83 to 0.91. For temporal domain parameters, the range was 0.74 to 0.91. Low absolute values of the coefficients of correlation between monoexponential decay markers (R, PW) and resonance shape markers (PRA, PRD) were observed (range, 0.23-0.38). Conclusion The feasibility and potential diagnostic utility of HiSS MRI in the prostate at 3 T without an endorectal coil was confirmed. Weak correlation between well-performing markers indicates that complementary information could be leveraged to further improve diagnostic accuracy.
- Subjects :
- Physics
Male
Reproducibility
Hiss
Logarithm
Receiver operating characteristic
Breast imaging
Prostatic Neoplasms
Reproducibility of Results
Pilot Projects
Magnetic Resonance Imaging
Article
030218 nuclear medicine & medical imaging
Correlation
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Distortion
Humans
Radiology, Nuclear Medicine and imaging
Image resolution
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15222594
- Volume :
- 86
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Magnetic resonance in medicine
- Accession number :
- edsair.doi.dedup.....86d2e5176c3cea2a01ed6995eb43bee6