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Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome
- Source :
- Lung. 195:323-332
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The acute respiratory distress syndrome (ARDS) represents a major challenge for clinicians as well as basic scientists. The mortality rate for ARDS has been maintained within the range of 40-52%. The authors have examined the involvement of the "cardiotonic steroids" in the pathogenesis and therapy of ARDS. We have studied the possible role of the bufadienolide, marinobufagenin (MBG), in the pathogenesis of ARDS in both a rat model of ARDS and in patients afflicted with that disorder. In addition, the potential therapeutic benefit of an antagonist of MBG, resibufogenin (RBG), in an animal model has been evaluated.A syndrome resembling human ARDS was produced in the rat by exposing the animals to 100% oxygen for 48 h. In other animals, RBG was administered to these "hyperoxic" rats, and the serum MBG was measured. In human ICU patients, urinary samples were examined for levels of MBG, and the values were compared to those obtained from other ICU patients admitted with diagnoses other than ARDS.(1) Exposure of rats to hyperoxia produced a histologic picture which resembled that of human ARDS. (2) Serum levels of MBG in the "hyperoxic" rats substantially exceeded those obtained in animals exposed to ambient oxygen levels and were reduced to normal by RBG. (3) In ARDS patients, substantial elevations in urinary MBG were obtained compared to those in non-ARDS ICU patients.MBG may serve as an important biomarker for the development of ARDS, and RBG may represent a preventative/therapy in this disorder.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
ARDS
Acute Lung Injury
Pulmonary Edema
Acute respiratory distress
Bufadienolide
Hyperoxia
030204 cardiovascular system & hematology
Pathogenesis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Animals
Humans
Medicine
In patient
Intensive care medicine
Respiratory Distress Syndrome
Marinobufagenin
business.industry
Mortality rate
Antagonist
medicine.disease
Rats
Up-Regulation
Bufanolides
Pulmonary Alveoli
Disease Models, Animal
030104 developmental biology
chemistry
Case-Control Studies
business
Biomarkers
Subjects
Details
- ISSN :
- 14321750 and 03412040
- Volume :
- 195
- Database :
- OpenAIRE
- Journal :
- Lung
- Accession number :
- edsair.doi.dedup.....86d1e5fa768921a68fa946de3fff0669
- Full Text :
- https://doi.org/10.1007/s00408-017-9989-1