Additional file 1 of Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer���s disease brain

Additional file 1. Table S1. Characteristics of the Mayo cohort. Table S2. Characteristics of the MSBB cohort. Table S3. Detailed results from the univariate regression analyses shown in Fig. 2A. Table S4. Association between cell type proportions and mtDNAcn in the DLPFC. Table S5. Association between number of mtDNA heteroplasmic mutations and age adjusted for pathologic diagnosis. Table S6. Datasets and analysis results deposited at the AD Knowledge Portal. Fig. S1. Log-transformed mtDNAcn values are approximately normally distributed. Fig. S2. Changes of the mtDNAcn are primarily associated with tau in the DLPFC. Fig. S3. Significant fraction of the APOE ��4 effect on mtDNAcn is mediated via AD pathologies. Fig. S4. Number of mtDNA heteroplasmic mutations in cortical regions is associated with age adjusted for sex, pathologic diagnosis, and mtDNAcn. Fig. S5. Mitochondrial content score and its relation to mtDNAcn, mtDNA heteroplasmy burden and AD-related phenotypes.