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Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial
- Source :
- Cancer Medicine, Cancer Medicine, Wiley, 2018, 7 (5), pp.1575-1577. ⟨10.1002/cam4.1403⟩
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- International audience; We describe the predictive value of BRCA1 gene status on trabectedin efficacy and found no correlation despite the mechanisms of action of this drug that rely on DNA repair systems.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
education
[SDV.CAN]Life Sciences [q-bio]/Cancer
law.invention
03 medical and health sciences
0302 clinical medicine
[SDV.CAN] Life Sciences [q-bio]/Cancer
Randomized controlled trial
law
Internal medicine
medicine
Radiology, Nuclear Medicine and imaging
Prospective cohort study
ComputingMilieux_MISCELLANEOUS
Trabectedin
Brca1 gene
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
business.industry
Clinical Cancer Research
medicine.disease
Predictive value
3. Good health
Clinical trial
Editorial
030104 developmental biology
030220 oncology & carcinogenesis
Predictive value of tests
Sarcoma
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
medicine.drug
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....86ca274c4cc82a24817ef9d04b1694bd