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Characterization of Nkx6-2-derived neocortical interneuron lineages
- Source :
- Cerebral Cortex (New York, NY)
- Publication Year :
- 2009
-
Abstract
- Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the caudal ganglionic eminence. The function of Nkx6-2 in directing the fate of those progenitors has, however, not been thoroughly analyzed. We used a combination of genetic inducible fate mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern. Furthermore, we extend the characterization of interneurons from the Nkx6-2 lineage through the application of electrophysiological methods. Analysis of these populations in Nkx6-2 null mice suggests that there is a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons in the absence of Nkx6-2 gene function.
- Subjects :
- 2805 Cognitive Neuroscience
Lineage (genetic)
animal structures
Interneuron
Ganglionic eminence
Cognitive Neuroscience
2804 Cellular and Molecular Neuroscience
610 Medicine & health
Neocortex
Biology
03 medical and health sciences
Cellular and Molecular Neuroscience
Mice
0302 clinical medicine
Fate mapping
Interneurons
medicine
Animals
Tissue Distribution
Transcription factor
Loss function
030304 developmental biology
Homeodomain Proteins
Mice, Knockout
genetic fate mapping
0303 health sciences
10242 Brain Research Institute
interganglionic sulcus
Articles
whole-cell physiology
mouse genetics
medicine.anatomical_structure
nervous system
loss of function
embryonic structures
Homeobox
570 Life sciences
biology
Calretinin
Neuroscience
030217 neurology & neurosurgery
Transcription Factors
Subjects
Details
- ISSN :
- 14602199
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Accession number :
- edsair.doi.dedup.....86bb489168e165fd7f86e0a805fa13a8