Back to Search
Start Over
Modern Clinician-initiated Clinical Trials to Determine Optimal Therapy for Multidrug-resistant Gram-negative Infections
- Source :
- Clinical Infectious Diseases. 71:433-439
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Treatment options for multidrug-resistant (MDR) gram-negative infection are growing. However, postregistration, pragmatic, and clinician-led clinical trials in this field are few, recruit small sample sizes, and experience deficiencies in design and operations. MDR gram-negative therapeutic trials are often inefficient, only evaluating a single antibiotic or strategy at a time. Novel clinical trial designs offer potential solutions by attempting to obtain clinically meaningful conclusions at the end or during a trial, for many treatment strategies, simultaneously. An integrated, consensus approach to MDR gram-negative infection trial design is crucial.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
medicine.drug_class
030106 microbiology
Antibiotics
MEDLINE
03 medical and health sciences
0302 clinical medicine
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria
Humans
Medicine
030212 general & internal medicine
Intensive care medicine
Clinical Trials as Topic
business.industry
Treatment options
Small sample
Therapeutic trial
Anti-Bacterial Agents
Multiple drug resistance
Clinical trial
Infectious Diseases
Treatment strategy
Gram-Negative Bacterial Infections
business
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....86b27ac7e7408bb411ac46212c51b17f