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Emergence, Transmission, and Potential Therapeutic Targets for the COVID-19 Pandemic Associated with the SARS-CoV-2
- Source :
- Cellular Physiology and Biochemistry, Vol 54, Iss 4, Pp 767-790 (2020)
- Publication Year :
- 2020
- Publisher :
- Cell Physiol Biochem Press GmbH and Co KG, 2020.
-
Abstract
- The pandemic of the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 at the end of 2019 marked the third outbreak of a highly pathogenic coronavirus affecting the human population in the past twenty years. Cross-species zoonotic transmission of SARS-CoV-2 has caused severe pathogenicity and led to more than 655,000 fatalities worldwide until July 28, 2020. Outbursts of this virus underlined the importance of controlling infectious pathogens across international frontiers. Unfortunately, there is currently no clinically approved antiviral drug or vaccine against SARS-CoV-2, although several broad-spectrum antiviral drugs targeting multiple RNA viruses have shown a positive response and improved recovery in patients. In this review, we compile our current knowledge of the emergence, transmission, and pathogenesis of SARS-CoV-2 and explore several features of SARS-CoV-2. We emphasize the current therapeutic approaches used to treat infected patients. We also highlight the results of in vitro and in vivo data from several studies, which have broadened our knowledge of potential drug candidates for the successful treatment of patients infected with and discuss possible virus and host-based treatment options against SARS-CoV-2. CA - Khairnar
- Subjects :
- Immunity, Herd
Physiology
viruses
Medizin
Global Health
Virus Replication
medicine.disease_cause
lcsh:Physiology
Drug Delivery Systems
Zoonoses
Pandemic
Medicine
lcsh:QD415-436
Coronavirus
education.field_of_study
lcsh:QP1-981
biology
Transmission (medicine)
Viral Vaccine
virus diseases
Endocytosis
Spike Glycoprotein, Coronavirus
Cytokines
RNA, Viral
Receptors, Virus
Coronavirus Infections
Cytokine Release Syndrome
COVID-19 Vaccines
Coronaviridae
Coronaviridae Infections
medicine.drug_class
Pneumonia, Viral
Population
Genome, Viral
Antiviral Agents
Virus
lcsh:Biochemistry
Betacoronavirus
Animals
Humans
education
Pandemics
COVID-19 Serotherapy
SARS-CoV-2
business.industry
Immunization, Passive
COVID-19
Viral Vaccines
Virus Internalization
biology.organism_classification
Virology
COVID-19 Drug Treatment
Antiviral drug
business
Forecasting
Peptide Hydrolases
Receptors, Coronavirus
Subjects
Details
- ISSN :
- 14219778 and 10158987
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....86af109dfb85fd84a9dc8c7aeba1bcc4