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The impact of dyslipidemia and oxidative stress on vasoactive mediators in patients with renal dysfunction
- Source :
- International urology and nephrology. 51(12)
- Publication Year :
- 2019
-
Abstract
- Hyperlipidemia and oxidative stress are indispensable features of chronic kidney disease (CKD) that favor the development of atherogenic plaques and cardiovascular disease (CVD). A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction. Therefore, therapeutic measures aimed at correcting dyslipidemia and alleviating oxidative stress could potentially protect against CVD in CKD patients. In this review, we discuss the relation between dyslipidemia, oxidative stress, and vasoactive mediators as well as the available treatment options against these disturbances in CKD patients.
- Subjects :
- Nephrology
medicine.medical_specialty
Urology
030232 urology & nephrology
Disease
030204 cardiovascular system & hematology
Bioinformatics
medicine.disease_cause
Nitric Oxide
03 medical and health sciences
0302 clinical medicine
Internal medicine
Hyperlipidemia
medicine
Humans
Renal Insufficiency, Chronic
Dyslipidemias
Endothelin-1
business.industry
PCSK9
Angiotensin II
medicine.disease
Oxidative Stress
Proprotein Convertase 9
business
Dyslipidemia
Oxidative stress
Kidney disease
Subjects
Details
- ISSN :
- 15732584
- Volume :
- 51
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International urology and nephrology
- Accession number :
- edsair.doi.dedup.....86a89692f83275a17b31edab8e6266b9