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Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery
- Source :
- Circulation, Circulation, 122(3), 273-U107. LIPPINCOTT WILLIAMS & WILKINS, CIRCULATION
- Publication Year :
- 2010
-
Abstract
- Background— Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown. Methods and Results— Here, we report that VEGF ∂/∂ mice with low vascular endothelial growth factor (VEGF) levels suffer defects in the regulation of resistance arteries. These defects are due to dysfunction and structural remodeling of the neuroeffector junction, the equivalent of a synapse between autonomic nerve endings and vascular smooth muscle cells, and to an impaired contractile smooth muscle cell phenotype. Notably, short-term delivery of a VEGF inhibitor to healthy mice also resulted in functional and structural defects of neuroeffector junctions. Conclusions— These findings uncover a novel role for VEGF in the maintenance of arterial neuroeffector function and may help us better understand how VEGF inhibitors cause vascular regulation defects in cancer patients.
- Subjects :
- Vascular Endothelial Growth Factor A
SYMPATHETIC-NERVOUS-SYSTEM
Vascular smooth muscle
muscle
SMOOTH-MUSCLE-CELLS
Gene Expression
Transgenic
Muscle, Smooth, Vascular
Neuroeffector junction
arteries
chemistry.chemical_compound
Mesenteric Arterie
Mice
Cardiovascular Disease
vasoconstriction
vascular endothelial growth factor
Medicine (all)
nervous system
Gene Transfer Techniques
arterie
Autonomic Nervous System Disease
MESENTERIC-ARTERIES
VEGF
Common
Mesenteric Arteries
Vascular endothelial growth factor B
Vascular endothelial growth factor
Vascular endothelial growth factor A
DIFFERENTIATION
medicine.anatomical_structure
Lac Operon
Cardiovascular Diseases
SURVIVAL
Smooth
Cardiology and Cardiovascular Medicine
smooth
Signal Transduction
EXPRESSION
medicine.medical_specialty
Neuroeffector
Carotid Artery, Common
Mice, Transgenic
RATS
Internal medicine
Vascular
Physiology (medical)
muscle, smooth
medicine
Animals
Autonomic Nervous System Diseases
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Vascular Resistance
Vasoconstriction
ERYTHRODYSESTHESIA
RECEPTOR
business.industry
Animal
Biology and Life Sciences
Kinase insert domain receptor
Gene Transfer Technique
Endocrinology
chemistry
Vascular resistance
Human medicine
Carotid Artery
business
Subjects
Details
- Language :
- English
- ISSN :
- 00097322
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....869af034c9a5edf6c835c5019c41bc07