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Effect of Lymph Node Count on Pathological Stage III Rectal Cancer with Preoperative Radiotherapy
- Source :
- Scientific Reports
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Lymph node (LN) status after surgery for rectal cancer is affected by preoperative radiotherapy. The purpose of this study was to perform a population-based evaluation of the impact of pathologic LN status after neoadjuvant radiotherapy on survival. A total of 1,650 patients receiving neoadjuvant chemotherapy in Surveillance, Epidemiology and End Results Program (SEER)-registered ypIII stage rectal cancer was analyzed. We identified the optimal cutoff for retrieved LNs as 10 (χ2 = 14.006, P 0.001), which was validated as an independent prognosis factors in a Cox regression model. Further analysis showed that the LN count was only a prognosis factor with the number from 8 to 16(except for 13).After the number 16, the 5-year survival rate decreased gradually. Collectively, our results confirmed that the number of LNs in yp III stage rectal patients was a prognosis factor only with the numbers from 8 to 16(except for 13). Using the total mesorectal excision technique with an adequate pathologic examination, a large number of LNs retrieved (≥17) might indicate worse tumor response grade and poorer survival.
- Subjects :
- Adult
Male
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Population
Urology
Article
Young Adult
Preoperative Care
medicine
Humans
Registries
Stage (cooking)
education
Survival rate
Lymph node
Survival analysis
Aged
Neoplasm Staging
Aged, 80 and over
education.field_of_study
Multidisciplinary
Rectal Neoplasms
business.industry
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Total mesorectal excision
Surgery
Radiation therapy
medicine.anatomical_structure
Databases as Topic
Multivariate Analysis
Female
Lymph Nodes
business
SEER Program
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....86978522ae80330d32aa1f4e59372b63