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Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity
- Source :
- Biochemical and Biophysical Research Communications. 468:196-201
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Dehydroepiandrosterone (DHEA) exerts a wide variety of therapeutic effects against medical disorders, such as diabetes and obesity. However, the molecular basis of DHEA action remains to be clarified. Previously, we reported that DHEA-enhanced dual specificity protein phosphatase, designated DDSP, is one of the target molecules of DHEA. To examine the role of DDSP in DHEA signaling, we generated mice that carry a DDSP transgene in which expression is driven by the CAG promoter (DDSP-Tg). DDSP-Tg mice weighed significantly less than wild-type (WT) control mice when a high fat diet was supplied (p
- Subjects :
- Leptin
medicine.medical_specialty
p38 mitogen-activated protein kinases
Transgene
Biophysics
Gene Expression
Mice, Obese
Dehydroepiandrosterone
Mice, Transgenic
Biology
Diet, High-Fat
p38 Mitogen-Activated Protein Kinases
Biochemistry
Internal medicine
Diabetes mellitus
medicine
Animals
Obesity
Molecular Biology
Lipogenesis
Thermogenesis
Cell Biology
medicine.disease
Endocrinology
Mutation
Basal metabolic rate
Protein Tyrosine Phosphatases
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 468
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....869029b408ae6f72d659b57673a9587f