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Non-infectious Intraocular Inflammation Following Intravitreal Anti-Vascular Endothelial Growth Factor Injection
- Source :
- Turkish Journal of Ophthalmology, Türk Oftalmoloji Dergisi, Vol 51, Iss 1, Pp 32-37 (2021)
- Publication Year :
- 2021
- Publisher :
- Galenos Publishing, 2021.
-
Abstract
- Objectives To evaluate the functional and anatomical results of patients with non-infectious intraocular inflammation (IOI) following intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of neovascular age-related macular degeneration (nAMD). Materials and methods The medical records of patients receiving anti-VEGF treatment for nAMD between January 2015 and March 2019 were retrospectively analyzed. Preoperative and postoperative routine ophthalmological examinations, central macular thickness, duration of inflammation, and follow-up time of the patients with non-infectious IOI following anti-VEGF injection were recorded. Results Non-infectious IOI was determined in 13 eyes (11 eyes with aflibercept, 2 eyes with ranibizumab) of 1,966 patients who received a total of 12,652 anti-VEGF (4,796 aflibercept and 7,856 ranibizumab) injections. IOI was detected after a mean of 7 injections (2-12 injections). All eyes had both anterior chamber reaction (Tyndall +1/+3) and vitritis (grade 1-3). None of the patients had pain, hypopyon, or fibrin reaction. Visual acuity progressed to baseline levels within 28.3 days. Vitritis continued with a mean of 40 days. All patients recovered with topical steroid therapy. In 11 eyes, injection of the same anti-VEGF agent was continued. No recurrence of IOI was observed in any patients. Conclusion Non-infectious IOI following intravitreal anti-VEGF injection typically occurs without pain, conjunctival injection, hypopyon, or fibrin and responds well to topical steroid therapy. Visual acuity returns to baseline levels within weeks according to the severity of inflammation.
- Subjects :
- Vascular Endothelial Growth Factor A
medicine.medical_specialty
Visual acuity
genetic structures
medicine.medical_treatment
intraocular inflammation
lcsh:Medicine
Angiogenesis Inhibitors
Hypopyon
Fibrin
lcsh:Ophthalmology
Ophthalmology
medicine
Humans
vitritis
Topical Steroid Therapy
Aflibercept
Retrospective Studies
Inflammation
biology
business.industry
lcsh:R
Anti-VEGF
Macular degeneration
medicine.disease
topical steroid
lcsh:RE1-994
Intravitreal Injections
biology.protein
Original Article
Ranibizumab
medicine.symptom
business
Topical steroid
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 21498709 and 21498695
- Volume :
- 51
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Turkish Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....868eed2d0175f29b9b8663c2f9574dc5