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Quantitative measures for redox signaling
- Source :
- Free Radical Biology and Medicine. 96:290-303
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Redox signaling is now recognized as an important regulatory mechanism for a number of cellular processes including the antioxidant response, phosphokinase signal transduction and redox metabolism. While there has been considerable progress in identifying the cellular machinery involved in redox signaling, quantitative measures of redox signals have been lacking, limiting efforts aimed at understanding and comparing redox signaling under normoxic and pathogenic conditions. Here we have outlined some of the accepted principles for redox signaling, including the description of hydrogen peroxide as a signaling molecule and the role of kinetics in conferring specificity to these signaling events. Based on these principles, we then develop a working definition for redox signaling and review a number of quantitative methods that have been employed to describe signaling in other systems. Using computational modeling and published data, we show how time- and concentration- dependent analyses, in particular, could be used to quantitatively describe redox signaling and therefore provide important insights into the functional organization of redox networks. Finally, we consider some of the key challenges with implementing these methods.
- Subjects :
- 0301 basic medicine
Systems biology
Computational biology
Biology
medicine.disease_cause
Biochemistry
Redox
Antioxidants
03 medical and health sciences
Physiology (medical)
medicine
chemistry.chemical_classification
Reactive oxygen species
030102 biochemistry & molecular biology
Mechanism (biology)
Hydrogen Peroxide
Cell biology
Redox metabolism
Kinetics
Oxidative Stress
030104 developmental biology
chemistry
Signal transduction
Reactive Oxygen Species
Peroxiredoxin
Oxidation-Reduction
Oxidative stress
Signal Transduction
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....867fb140d4a707c8a149d3d3d4aea551