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Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications
- Source :
- Advanced Healthcare Materials. 7:1701035
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Poly(lactic-co-glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical-chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.
- Subjects :
- Scaffold
Biomedical Engineering
Pharmaceutical Science
Nanotechnology
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
chemistry.chemical_compound
Drug Delivery Systems
Animals
Humans
chemistry.chemical_classification
Bioconjugation
Tissue Engineering
Tissue Scaffolds
Regeneration (biology)
Biomedical polymers
technology, industry, and agriculture
Polymer
021001 nanoscience & nanotechnology
0104 chemical sciences
PLGA
chemistry
Drug delivery
Surface modification
0210 nano-technology
Polyglycolic Acid
Subjects
Details
- ISSN :
- 21922640
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Advanced Healthcare Materials
- Accession number :
- edsair.doi.dedup.....867f8082d9ce4863e3b9899249c03d09