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Correction: Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver
- Source :
- PLoS ONE, Vol 12, Iss 9, p e0184610 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- Ubiquitin is a crucial post-translational modification regulating numerous cellular processes, but its role in metabolic disease is not well characterized. In this study, we identified the in vivo ubiquitin-modified proteome in rat liver and determined changes in this ubiquitome under acute insulin stimulation and high-fat and sucrose diet-induced insulin resistance. We identified 1267 ubiquitinated proteins in rat liver across diet and insulin-stimulated conditions, with 882 proteins common to all conditions. KEGG pathway analysis of these proteins identified enrichment of metabolic pathways, TCA cycle, glycolysis/gluconeogenesis, fatty acid metabolism, and carbon metabolism, with similar pathways altered by diet and insulin resistance. Thus, the rat liver ubiquitome is sensitive to diet and insulin stimulation and this is perturbed in insulin resistance.
- Subjects :
- Male
Sucrose
Proteome
medicine.medical_treatment
Citric Acid Cycle
lcsh:Medicine
Text mining
Ubiquitin
medicine
Animals
Insulin
Rats, Wistar
lcsh:Science
Multidisciplinary
biology
Chemistry
business.industry
Fatty Acids
lcsh:R
Gluconeogenesis
Correction
Lipid Metabolism
Dietary Fats
Carbon
Diet
Rats
Liver
Biochemistry
Rat liver
biology.protein
lcsh:Q
Insulin Resistance
business
Glycolysis
Protein Processing, Post-Translational
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....867d59a5d795e9811608ecc5bba5bb4f