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Tribbles Gene Expression Profiles in Colorectal Cancer
- Source :
- Gastrointestinal Disorders, Vol 3, Iss 21, Pp 218-236 (2021), Gastrointestinal Disorders, Volume 3, Issue 4, Pages 21-236, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death due to cancer in the world. Therefore, the identification of novel druggable targets is urgently needed. Tribbles proteins belong to a pseudokinase family, previously recognized in CRC as oncogenes and potential therapeutic targets. Here, we analyzed the expression of TRIB1, TRIB2, and TRIB3 simultaneously in 33 data sets from CRC based on available GEO profiles. We show that all three Tribbles genes are overrepresented in CRC cell lines and primary tumors, though depending on specific features of the CRC samples. Higher expression of TRIB2 in the tumor microenvironment and TRIB3 overexpression in an early stage of CRC development, unveil a potential and unexplored role for these proteins in the context of CRC. Differential Tribbles expression was also explored in diverse cellular experimental conditions where either genetic or pharmacological approaches were used, providing novel hints for future research. This comprehensive bioinformatic analysis provides new insights into Tribbles gene expression and transcript regulation in CRC. info:eu-repo/semantics/publishedVersion
- Subjects :
- Colorectal cancer
oncogenes
Druggability
Context (language use)
colorectal cancer
Computational biology
RC799-869
Biology
03 medical and health sciences
0302 clinical medicine
Transcriptional regulation
medicine
transcriptional regulation
Gene
030304 developmental biology
0303 health sciences
Tumor microenvironment
Tribbles
Cancer
Oncogenes
Diseases of the digestive system. Gastroenterology
medicine.disease
digestive system diseases
3. Good health
TRIB3
030220 oncology & carcinogenesis
gene expression
Medicine
Gene expression
Subjects
Details
- Language :
- English
- ISSN :
- 26245647
- Volume :
- 3
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Gastrointestinal Disorders
- Accession number :
- edsair.doi.dedup.....867507543c61981d5d3539e4615a39de