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High attrition before and after ART initiation among youth (15–24 years of age) enrolled in HIV care
- Publication Year :
- 2014
-
Abstract
- OBJECTIVES: To compare pre and post-ART attrition between youth (15-24 years) and other patients in HIV care and to investigate factors associated with attrition among youth. DESIGN: Cohort study utilizing routinely collected patient-level data from 160 HIV clinics in Kenya Mozambique Tanzania and Rwanda. METHODS: Patients at least 10 years of age enrolling in HIV care between 01/05 and 09/10 were included. Attrition (loss to follow-up or death 1 year after enrollment or ART initiation) was compared between youth and other patients using multivariate competing risk (pre-ART) and traditional (post-ART) Cox proportional hazards methods accounting for within-clinic correlation. Among youth patient-level and clinic-level factors associated with attrition were similarly assessed. RESULTS: A total of 312335 patients at least 10 years of age enrolled in HIV care; 147936 (47%) initiated ART 17% enrolling in care and 10% initiating ART were youth. Attrition before and after ART initiation was substantially higher among youth compared with other age groups. Among youth nonpregnant women experienced lower pre-ART attrition than men [sub-division hazard ratio = 0.90 95% confidence interval (CI): 0.86-0.94] while both pregnant [adjusted hazard ratio (AHR) = 0.85 95% CI: 0.74-0.97] and nonpregnant (AHR = 0.79 95% CI: 0.73-0.86) female youth experienced lower post-ART attrition than men. Youth attending clinics providing sexual and reproductive health services including condoms (AHR = 0.47 95% CI: 0.32-0.70) and clinics offering adolescent support groups (AHR = 0.73 95% CI: 0.52-1.0) experienced significantly lower attrition after ART initiation. CONCLUSION: Youth experienced substantially higher attrition before and after ART initiation compared with younger adolescents and older adults. Adolescent-friendly services were associated with reduced attrition among youth particularly after ART initiation.
- Subjects :
- Gerontology
Adult
Male
Adolescent
Immunology
Population
HIV Infections
Article
Cohort Studies
Young Adult
Acquired immunodeficiency syndrome (AIDS)
Ambulatory care
Pregnancy
Antiretroviral Therapy, Highly Active
medicine
Ambulatory Care
Immunology and Allergy
Humans
Attrition
Lost to follow-up
education
Child
Reproductive health
education.field_of_study
business.industry
Incidence
Hazard ratio
Middle Aged
medicine.disease
Infectious Diseases
Anti-Retroviral Agents
Africa
Female
Lost to Follow-Up
business
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8672a86f8fea347512529bc17a3e11aa