Supplemental Figure S4 from Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo

Supplemental Figure S4: (A) S2013 mouse demonstrate localization of V7-750 probe, but not K7-750 to the region of the tumor bed, signal intensity in the pancreas tumor of S2013 mice with injection of V7-750 is 578.3 MSOT a.u., compared to 5.1 for K7-750 with p=0.0005. K7-750 signal was largely localized in the kidney.(B) Orthogonal views of the pancreatic tumor bed at 4 hours demonstrate distribution of V7-750 probe signal throughout the tumor bed at 4 hours, while minimal accumulation is observed with K7-750.