Back to Search
Start Over
Metastatic appendiceal cancer treated with Yttrium 90 radioembolization and systemic chemotherapy: A case report
- Source :
- World Journal of Radiology
- Publication Year :
- 2019
- Publisher :
- Baishideng Publishing Group Inc, 2019.
-
Abstract
- BACKGROUND Primary appendiceal cancers are rare, and they generally present with liver and/or peritoneal metastases. Currently there are no guidelines to treat metastatic appendiceal cancer, and hence they are treated as metastatic colorectal cancer. Combining Yttrium 90 (Y-90) radioembolization (RE) with systemic chemotherapy early in the treatment of right sided colon cancers has been shown to improve survival. Based on this data, a combination of systemic chemotherapy and Y-90 RE was used to treat a case of metastatic appendiceal cancer. CASE SUMMARY A 76-year-old male presented to the emergency room with progressive right lower quadrant pain. A Computed Tomography of the abdomen and pelvis was performed which showed acute appendicitis and contained perforation. Urgent laparoscopic appendectomy was then followed by histological analysis, which was significant for appendiceal adenocarcinoma. After complete workup he underwent right hemicolectomy and lymph node dissection. He received adjuvant chemotherapy as the local lymph nodes were positive. Follow-up imaging was significant for liver metastasis. Due to rapid growth of the liver lesions and new peritoneal nodules, the patient was treated with a combination of Y-90 RE and folinic acid, fluorouracil, and irinotecan with bevacizumab and not microwave ablation as previously planned. Follow up imaging demonstrated complete response of the liver lesions. At 12-mo follow-up, the patient continued to enjoy good quality of life with no recurrent disease. CONCLUSION Utilization of Y-90 RE concomitantly with systemic chemotherapy early in the treatment of appendiceal cancer may provide improved control of this otherwise aggressive cancer.
- Subjects :
- musculoskeletal diseases
Oncology
medicine.medical_specialty
Colorectal cancer
chemistry.chemical_element
030218 nuclear medicine & medical imaging
03 medical and health sciences
Liver metastases
0302 clinical medicine
Internal medicine
Case report
medicine
Radioembolization
Systemic chemotherapy
business.industry
Cancer
Yttrium
medicine.disease
Hyperthermic intraperitoneal chemotherapy
surgical procedures, operative
Appendix cancer with peritoneal metastasis
chemistry
Yttrium-90 microspheres
Yttrium 90 microspheres
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 19498470
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- World Journal of Radiology
- Accession number :
- edsair.doi.dedup.....865cc2d61a0125e98a41bbfc4b3d785c