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Circular RNAs: emerging cancer biomarkers and targets
- Source :
- Journal of Experimental & Clinical Cancer Research : CR, Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles in the development and progression of diseases including cancer. In particular, circRNAs have shown great potential in cancer diagnosis, prognosis, and therapy. In this review, we provide an overview of the biogenesis and characteristics of circRNAs, succinctly describe their functions, and comprehensively discuss about the recent advances in the roles of circRNAs in cancer with an emphasis on their clinical values. Electronic supplementary material The online version of this article (10.1186/s13046-017-0624-z) contains supplementary material, which is available to authorized users.
- Subjects :
- Target
0301 basic medicine
Cancer Research
Review
Computational biology
Biology
Bioinformatics
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Neoplasms
Biomarkers, Tumor
medicine
Humans
Gene Regulatory Networks
Cancer
Competing endogenous RNA
RNA
RNA, Circular
ceRNA
Biomarker
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Biomarker (cell)
Gene Expression Regulation, Neoplastic
CircRNA
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Disease Progression
Cancer biomarkers
Closed loop
Biogenesis
Subjects
Details
- ISSN :
- 17569966
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental & Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....865c21ea9e74af3f92fa475728d5094b