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Factors affecting decisions to accept or decline cystic fibrosis carrier testing/screening: A theory-guided systematic review
- Source :
- Genetics in Medicine. 9:442-450
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- To assess factors affecting individuals' decision to accept or decline cystic fibrosis carrier testing/screening, as reported in studies published until December 2006. The Health Belief Model guided classification of each factor, and the studies' methodological quality was assessed.A three-stage search and retrieval process, alongside application of specific inclusion/exclusion criteria, yielded 40 studies (in 35 articles). For each reviewed study, authors abstracted and organized selected data into a matrix and assigned a methodological quality score.The four most frequently identified acceptance factors included three Health Belief Model factors and one non-Health Belief Model factor: perceived benefits of undergoing cystic fibrosis carrier testing/screening, weaker perception of barriers to cystic fibrosis carrier testing/screening, fewer/no children or desiring children, and research-related factors (non-Health Belief Model factor construct). All four most frequent factors associated with declining testing were Health Belief Model factor constructs: perceived barriers to obtaining cystic fibrosis carrier testing/screening, parity, lack of knowledge, and weaker perception of benefits of undergoing cystic fibrosis carrier testing/screening. The average methodological quality of the studies was 10.2 (SD=3.2; range, 5-18 points).The methodological and theoretical quality of this body of literature could be substantially improved if researchers employed theory-based approaches, tested (and reported) the validity/reliability of their own data, and employed multivariate statistical analyses and/or better controlled research designs. Improving the quality of future studies may allow better inferences regarding the relative contribution of each factor identified in this review to individuals' decision-making process.
- Subjects :
- Male
medicine.medical_specialty
Cystic Fibrosis
business.industry
Genetic Carrier Screening
Genetic Counseling
Models, Theoretical
medicine.disease
Cystic fibrosis
Research Design
Multivariate Analysis
Cystic fibrosis carrier
Humans
Medicine
Female
Genetic Testing
business
Intensive care medicine
Genetics (clinical)
Subjects
Details
- ISSN :
- 10983600
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Genetics in Medicine
- Accession number :
- edsair.doi.dedup.....8657e1feb98c41bb35785268328bbdbe