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Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity
- Source :
- BioMed Research International, BioMed Research International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Background. Human adenoviruses (HAdVs) are commonly causing respiratory disease. We molecularly genotyped HAdV circulating in Chinese hospitalized children with respiratory infections and summarized the clinical profiles and common inflammatory biomarkers, so as to better determine their associations with disease severity. Method. Children with respiratory single HAdV infection cases that occurred from December 2017 to March 2019 were enrolled for a cross-sectional study. Clinical/laboratory features based on the genotypes of respiratory HAdV infection were reviewed for comparative analysis. Results. A total of 84 patients were enrolled, and HAdV types were identified from 82 patients. Species B (HAdV-7, 44%; HAdV-3, 43%, and HAdV-14, 5%) was the most common, followed by C (HAdV-2, 4% and HAdV-1, 1%) and E (HAdV-4, 1%). Severe HAdV infection and HAdV-7 infection groups were associated with significantly longer duration of fever and hospitalized days, higher morbidity of tachypnea/dyspnea, more pleural effusion, more respiratory rales, more frequently required mechanical ventilation, and significantly higher fatality rate. The elevated procalcitonin (PCT) and C-reactive protein (CRP) levels were significantly associated with severe HAdV infection. Conclusions. HAdV-7 and HAdV-3 were the most common types among children with respiratory adenovirus infection; vaccines against these two genotypes are in urgent need. PCT and CRP are significantly associated with the severity of HAdV infection.
- Subjects :
- Male
0301 basic medicine
Pleural effusion
Adenoviridae Infections
Gene Expression
Severity of Illness Index
Procalcitonin
Case fatality rate
Respiratory system
Child
Respiratory Tract Infections
Phylogeny
Molecular Epidemiology
Respiratory disease
virus diseases
General Medicine
C-Reactive Protein
Child, Preschool
Medicine
Female
medicine.symptom
Research Article
medicine.medical_specialty
Adolescent
Genotype
Article Subject
030106 microbiology
Tachypnea
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Internal medicine
Severity of illness
medicine
Humans
Adenovirus infection
General Immunology and Microbiology
business.industry
Adenoviruses, Human
Infant
Length of Stay
medicine.disease
Respiration, Artificial
Survival Analysis
eye diseases
Pleural Effusion
Cross-Sectional Studies
Dyspnea
030104 developmental biology
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....86502b301f806c58a47af69d2964cc8f
- Full Text :
- https://doi.org/10.1155/2020/4357910