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High-Grade Gliomas Located in the Right Hemisphere Are Associated With Worse Quality of Life
- Source :
- World Neurosurgery. 149:e721-e728
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background The impact of glioma location on quality of life (QOL) has not been conclusively studied, possibly due to the prohibitively high sample size that standard statistical analyses would require and the inherent heterogeneity of this disease. By using a novel algorithm, we investigated the impact of tumor location on QOL in a limited set of 53 consecutive patients. Methods The glial tumors of 53 consecutive patients were segmented and registered to a standardized atlas. The Euclidian distance between 90 brain regions and each tumor's margin was calculated and correlated to the patient's self-reported QOL as measured by the Sherbrooke Neuro-Oncology Assessment Scale questionnaire. Results QOL was not correlated to tumor volume, though a significant correlation was observed with its proximity to these areas: right supramarginal gyrus, right rolandic operculum, right superior temporal gyrus, right middle temporal gyrus, right angular gyrus, and right inferior parietal lobule. Interestingly, all identified areas are in the right hemisphere, and localized in the temporoparietal region. We postulate that the adverse relation between proximity to these areas and QOL results from disruption in visuospatial functioning. Conclusions Although the areas identified in this study are traditionally considered non-eloquent areas, tumor proximity to these regions showed more impact on QOL than any other brain regions. We postulate that this effect is mediated via an adverse impact on the visuospatial functioning.
- Subjects :
- Adult
Male
medicine.medical_specialty
Right angular gyrus
Audiology
Correlation
03 medical and health sciences
0302 clinical medicine
Quality of life
Parietal Lobe
Glioma
Humans
Medicine
Right superior temporal gyrus
Tumor location
Right hemisphere
Brain Neoplasms
business.industry
Brain
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Temporal Lobe
humanities
Sample size determination
030220 oncology & carcinogenesis
Quality of Life
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18788750
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- World Neurosurgery
- Accession number :
- edsair.doi.dedup.....864725c22befef4ead9e253f943632bf