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Evaluation of Rifaximin in Management of Hepatic Encephalopathy
- Source :
- Journal of the Egyptian Society of Parasitology. 44:677-685
- Publication Year :
- 2014
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2014.
-
Abstract
- This study evaluated the efficacy of rifaximin versus lactulose in the treatment of hepatic encephalopathy (HE). The study population included 50 patients who were diagnosed to have signs of the first to third degree HE, according to the West Haven criteria and classified into two groups. GI: included 25 patients who had HE and were treated with lactulose syrup (laxolac) 90 ml daily divided into 3 doses for 7 days. GII: included 25 patients who had HE and were treated with rifaximin 1200 mg daily divided into 3 doses for 7 days. Patients in both groups also received other measures of treatment of HE as daily enema and protein restriction. Rifaximin significantly improved various subjective and measurable components of HE including mental status, behavior, asterixis, and serum ammonia concentration. In acute HE of grade 1 to grade 3, rifaximin may be a good alternative to non-absorbable disaccharides as it is broad spectrum, non-absorbable antibiotic with rapid action and little side effects. It is better tolerated, associated with less frequent and shorter hospitalization in comparison to lactulose.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Antibiotics
Enema
Gastroenterology
Rifaximin
law.invention
Lactulose
chemistry.chemical_compound
Anti-Infective Agents
Randomized controlled trial
law
Internal medicine
medicine
Humans
Hepatic encephalopathy
Asterixis
business.industry
medicine.disease
Rifamycins
chemistry
Hepatic Encephalopathy
Population study
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 11100583
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of the Egyptian Society of Parasitology
- Accession number :
- edsair.doi.dedup.....86441555d0ff2d48a8583bc56aca374c