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Longitudinal Femoral Cartilage T2 Relaxation Time and Thickness Changes with Fast Sequential Radiographic Progression of Medial Knee Osteoarthritis-Data from the Osteoarthritis Initiative (OAI)
- Source :
- Journal of Clinical Medicine, Volume 10, Issue 6, Journal of Clinical Medicine, Vol 10, Iss 1294, p 1294 (2021)
- Publication Year :
- 2020
-
Abstract
- This study tested for longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA). From the Osteoarthritis Initiative (OAI) database, nineteen knees fulfilled the inclusion criteria, which included medial femorotibial OA and sequential progression from Kellgren–Lawrence grade (KL) 1 to KL2 to KL3 within five years. Median T2 value and mean thickness were calculated for six condylar volumes of interest (VOIs<br />medial/lateral anterior, central, posterior) and six sub-VOIs (medial/lateral anterior external, central, internal). T2 value and thickness changes between severity timepoints were tested using repeated statistics. T2 values increased between KL1 and KL2 and between KL1 and KL3 in the medial compartment (p ≤ 0.02), whereas both increases and decreases were observed between the same timepoints in the lateral compartment (p ≤ 0.02). Cartilage thickness decreased in VOI/subVOIs of the medial compartment from KL1 to KL2 and KL3 (p ≤ 0.014). Cartilage T2 value and thickness changes varied spatially over the femoral condyles. While all T2 changes occurred in the early radiographic stages of OA, thickness changes occurred primarily in the later stages. These data therefore support the use of T2 relaxation time analyses in methods of detecting disease-related change during early OA, a valuable period for therapeutic interventions.
- Subjects :
- musculoskeletal diseases
Radiography
lcsh:Medicine
knee
Osteoarthritis
Condyle
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
joint
morphology
articular-cartilage
medicine
magnetic resonance imaging
three-dimensional
patterns
cartilage
mri
030203 arthritis & rheumatology
medicine.diagnostic_test
business.industry
spatial variations
Compartment (ship)
Cartilage
lcsh:R
Magnetic resonance imaging
General Medicine
t-1-rho
medicine.disease
Femoral cartilage
osteoarthritis
medicine.anatomical_structure
composition
T2 relaxation
women
participants
business
Nuclear medicine
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....8641dce1a02e3afae63a103f9caa9078