The ansa subthalamica as a substrate for DBS-induced manic symptoms

Over the years, important insight on the neurocircuitry of psychiatric symptoms have emerged from side effects recorded during deep brain stimulation (DBS). We have recently treated obesity in Prader Willi syndrome (PWS) using lateral hypothalamic region (LH) DBS[1Franco R.R. Fonoff E.T. Alvarenga P.G. Alho E.J.L. Lopes A.C. Hoexter M.Q. et al.Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome.JAMA Netw Open. 2018; 1e185275Crossref Scopus (1) Google Scholar, 2Talakoub O. Paiva R.R. Milosevic M. Hoexter M.Q. Franco R. Alho E. et al.Lateral hypothalamic activity indicates hunger and satiety states in humans.Ann Clin Transl Neurol. 2017; 4: 897-901Crossref Scopus (2) Google Scholar] and noticed that two out of four patients developed stimulation-induced hypomania/mania.