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The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review
- Source :
- Nutrients, Vol 11, Iss 2, p 462 (2019), Nutrients
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) is currently the most common feature of chronic liver disease. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD, and one of its risk factors is hyperglycemia. The chronic ingestion of excessive amounts of high-fructose corn syrup is associated with an increased prevalence of fatty liver. Under hyperglycemic conditions, advanced glycation end-products (AGEs) are generated through a non-enzymatic glycation reaction between the ketone or aldehyde groups of sugars and amino groups of proteins. Glyceraldehyde (GA) is a metabolic intermediate of sugars, and GA-derived AGEs (known as toxic AGEs (TAGE)) have been implicated in the development of NASH. TAGE accumulates more in serum or liver tissue in NASH patients than in healthy controls or patients with simple steatosis. Furthermore, the TAGE precursor, GA, causes cell damage through protein dysfunctions by TAGE modifications and induces necrotic-type hepatocyte death. Intracellular TAGE may leak outside of necrotic-type cells. Extracellular TAGE then induce inflammatory or fibrotic responses related to the pathology of NASH in surrounding cells, including hepatocytes and hepatic stellate cells. This review focuses on the contribution of TAGE to the pathology of NASH, particularly hepatic cell death related to NASH.
- Subjects :
- Glycation End Products, Advanced
0301 basic medicine
medicine.medical_specialty
glyceraldehyde (GA)
non-alcoholic steatohepatitis (NASH)
lcsh:TX341-641
Review
Chronic liver disease
advanced glycation end-products (AGEs)
digestive system
glyceraldehyde-derived AGEs
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Glycation
Internal medicine
Humans
Medicine
toxic AGEs (TAGE)
Cell damage
hepatocyte stellate cell (HSCs)
Nutrition and Dietetics
business.industry
Fatty liver
nutritional and metabolic diseases
medicine.disease
digestive system diseases
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Liver
030220 oncology & carcinogenesis
Hepatocyte
Hepatic stellate cell
hepatocytes
Steatohepatitis
business
lcsh:Nutrition. Foods and food supply
non-alcoholic fatty liver disease (NAFLD)
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....863e667e75692559bfffc93708f1c8f6
- Full Text :
- https://doi.org/10.3390/nu11020462