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Cause of Preterm Birth as a Prognostic Factor for Mortality
- Source :
- Clinical and experimental obstetrics & gynecology, Clinical and experimental obstetrics & gynecology, Irog Canada Inc., 2016, 127 (1), pp.40-48. ⟨10.1097/AOG.0000000000001179⟩, Clinical and experimental obstetrics & gynecology, 2016, 127 (1), pp.40-48. ⟨10.1097/AOG.0000000000001179⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- To investigate the association of the cause of preterm birth on in-hospital mortality of preterm neonates born from 24 to 34 weeks of gestation.L'Etude épidémiologique sur les petits âges gestationnels (EPIPAGE)-2 is a prospective, nationwide, population-based cohort of very preterm births. After dividing causes of preterm birth into six mutually exclusive groups, we analyzed the association of each cause with in-hospital deaths of preterm neonates born alive with adjustment for organizational, maternal, and obstetric factors.The analysis included 3,138 singleton live births from 24 to 34 weeks of gestation with a newborn in-hospital mortality rate of 5.0% (95% confidence interval 4.5-5.7). Preterm labor was the most frequent cause of preterm birth (n=1,293 [43.5%]) followed by preterm premature rupture of membranes (n=765 [23.9%]), hypertensive disorders without suspected fetal growth restriction (n=397 [12.7%]), hypertensive disorders with suspected fetal growth restriction (n=408 [10.9%]), placental abruption after an uncomplicated pregnancy (n=92 [3.0%]), and suspected fetal growth restriction without hypertensive disorders (n=183 [5.9%]). Neonates born because of suspected fetal growth restriction with or without hypertensive disorders (adjusted odds ratio [OR] 3.0 [1.9-4.7] and adjusted OR 2.3 [1.1-4.6], respectively) had higher adjusted risks of in-hospital death than those born after preterm labor. Risks of in-hospital mortality for preterm births caused by preterm premature rupture of membranes (adjusted OR 1.3 [0.9-1.9]), hypertensive disorders without fetal growth restriction (adjusted OR 0.7 [0.4-1.4]), or placental abruption (adjusted OR 1.6 [0.7-3.7]) were similar to those born after preterm labor.Among neonates born alive before 34 weeks of gestation, only those born because of suspected fetal growth restriction have a higher mortality risk than those born after preterm labor.
- Subjects :
- Fetal Membranes, Premature Rupture
MESH: Premature Birth
pregnancy disorders
Intrauterine growth restriction
morbidity
0302 clinical medicine
MESH: Pregnancy
Pregnancy
Risk Factors
MESH: Risk Factors
MESH: Gestational Age
Infant Mortality
neonatal outcomes
MESH: Abruptio Placentae
Medicine
MESH: Infant Mortality
Hospital Mortality
Prospective Studies
MESH: Obstetric Labor, Premature
Prospective cohort study
education.field_of_study
030219 obstetrics & reproductive medicine
Fetal Growth Retardation
Obstetrics
subtypes
MESH: Infant, Newborn
Obstetrics and Gynecology
Gestational age
cohort
gestational-age infant
Prognosis
MESH: Infant
3. Good health
Premature birth
MESH: Young Adult
Cohort
Premature Birth
Female
France
delivery
Adult
medicine.medical_specialty
intrauterine growth restriction
Population
education
MESH: Fetal Growth Retardation
MESH: Fetal Membranes, Premature Rupture
weight infants
Gestational Age
survival
MESH: Prognosis
03 medical and health sciences
Young Adult
Obstetric Labor, Premature
030225 pediatrics
Humans
MESH: Hospital Mortality
MESH: Hypertension, Pregnancy-Induced
Abruptio Placentae
MESH: Humans
business.industry
Infant, Newborn
Infant
MESH: Adult
Hypertension, Pregnancy-Induced
medicine.disease
Infant mortality
MESH: Prospective Studies
MESH: France
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
MESH: Female
Subjects
Details
- Language :
- English
- ISSN :
- 03906663
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental obstetrics & gynecology, Clinical and experimental obstetrics & gynecology, Irog Canada Inc., 2016, 127 (1), pp.40-48. ⟨10.1097/AOG.0000000000001179⟩, Clinical and experimental obstetrics & gynecology, 2016, 127 (1), pp.40-48. ⟨10.1097/AOG.0000000000001179⟩
- Accession number :
- edsair.doi.dedup.....86350ddfafbb55baebc5b29c11a2b352