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Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
- Source :
- Blood. 80:2584-2593
- Publication Year :
- 1992
- Publisher :
- American Society of Hematology, 1992.
-
Abstract
- FLT3, a receptor belonging to the FMS/KIT family and localized to 13q12, could play a role in the biology of early hematopoietic progenitor cells. Because FMS and KIT are expressed in both normal progenitors and myeloid leukemias, we looked for FLT3 expression in fresh human leukemic cells using Northern blot analysis. High levels of FLT3 expression were detected in 92% of the cases of acute myeloid leukemia (AML) tested, ranging from the M1 to the M5 stages of differentiation assessed in the French-American-British classification. Immature (MO) AML cells, biphenotypic leukemias, and AML with megakaryocytic differentiation (M7 subtype) also expressed the FLT3 transcript. FLT3 was also expressed at high levels in acute lymphoid leukemias of T and B origins. Finally, it was not expressed in chronic myeloid leukemias in chronic phase, whereas it was expressed in most blast crisis samples. This pattern of expression of FLT3 contrasts with the expression of FMS and KIT restricted to myeloid leukemias, and suggests that the FLT3 product could play a role in the expansion of the leukemic blasts of both the myeloid and lymphoid lineages.
- Subjects :
- Myeloid
T-Lymphocytes
Immunology
Gene Expression
Biology
Biochemistry
Monocytes
fluids and secretions
Proto-Oncogene Proteins
hemic and lymphatic diseases
Gene expression
medicine
Humans
RNA, Messenger
Northern blot
Progenitor cell
B-Lymphocytes
Chromosomes, Human, Pair 13
Nucleic Acid Hybridization
Myeloid leukemia
hemic and immune systems
Genes, fms
Cell Biology
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Blotting, Northern
medicine.disease
Blot
Leukemia, Myeloid, Acute
Proto-Oncogene Proteins c-kit
Leukemia
medicine.anatomical_structure
embryonic structures
Cancer research
Chromosome Deletion
DNA Probes
Granulocytes
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....861d0c5505b3a8fdb83e1fa949144553