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Pycnogenol Ameliorates Depression-Like Behavior in Repeated Corticosterone-Induced Depression Mice Model
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Oxidative stress is considered to be a mechanism of major depression. Pycnogenol (PYC) is a natural plant extract from the bark ofPinus pinasterAiton and has potent antioxidant activities. We studied the ameliorative effect of PYC on depression-like behavior in chronic corticosterone- (CORT-) treated mice for 20 days. After the end of the CORT treatment period, PYC (0.2 mg/mL) was orally administered in normal drinking water. Depression-like behavior was investigated by the forced swimming test. Immobility time was significantly longer by CORT exposure. When the CORT-treated mice were supplemented with PYC, immobility time was significantly shortened. Our results indicate that orally administered PYC may serve to reduce CORT-induced stress by radical scavenging activity.
- Subjects :
- Gerontology
Male
medicine.medical_specialty
endocrine system
Antioxidant
Article Subject
medicine.medical_treatment
lcsh:Medicine
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Antioxidants
chemistry.chemical_compound
Mice
Corticosterone
Internal medicine
medicine
polycyclic compounds
Psychological stress
Animals
Depression (differential diagnoses)
Swimming
Flavonoids
Depressive Disorder
General Immunology and Microbiology
business.industry
Depression
Plant Extracts
lcsh:R
General Medicine
Treatment period
Mice, Inbred C57BL
Disease Models, Animal
Oxidative Stress
Endocrinology
chemistry
business
Oxidative stress
Stress, Psychological
hormones, hormone substitutes, and hormone antagonists
Behavioural despair test
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....8605888fc6fe95c67b15bb7d6a1e23cc