Back to Search Start Over

Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures

Authors :
Xiaole Hu
Chan Jin Kim
Shine K. Albert
Ji Eun Park
So Jung Park
Source :
ACS Nano. 14:2276-2284
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.

Details

ISSN :
1936086X and 19360851
Volume :
14
Database :
OpenAIRE
Journal :
ACS Nano
Accession number :
edsair.doi.dedup.....86052d20cf2fc8bc55301ba49d82e2dd
Full Text :
https://doi.org/10.1021/acsnano.9b09312