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Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures
- Source :
- ACS Nano. 14:2276-2284
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- We report the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Dual-bioactive block copolymers composed of DNA and amino acid-based polymers (DNA-b-poly(amino acid)) were synthesized by coupling oligonucleotides to phenylalanine (Phe)-based polymers. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with diverse and unusual low-dimensional structures.
- Subjects :
- Polymers
Surface Properties
Metal Nanoparticles
General Physics and Astronomy
Phenylalanine
Peptide
02 engineering and technology
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
General Materials Science
Amino Acids
Particle Size
chemistry.chemical_classification
Molecular Structure
Oligonucleotide
Chemistry
Hydrolysis
General Engineering
Rational design
DNA
Polymer
021001 nanoscience & nanotechnology
Combinatorial chemistry
Nanostructures
0104 chemical sciences
Amino acid
Biocatalysis
Gold
Self-assembly
Peptides
0210 nano-technology
Peptide Hydrolases
Subjects
Details
- ISSN :
- 1936086X and 19360851
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- ACS Nano
- Accession number :
- edsair.doi.dedup.....86052d20cf2fc8bc55301ba49d82e2dd
- Full Text :
- https://doi.org/10.1021/acsnano.9b09312