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Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial
- Source :
- The journal of sexual medicine. 3(3)
- Publication Year :
- 2006
-
Abstract
- Introduction. Erectile dysfunction (ED) can significantly impact a man's relationships and well-being. Aim. We assessed changes in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction in men with ED using the validated Self-Esteem And Relationship questionnaire (SEAR). Methods. This was a 12-week, double-blind, placebo-controlled, flexible-dose (25, 50, 100 mg, as needed) interna- tional study of sildenafil in men ≥18 years of age in Mexico, Brazil, Australia, and Japan. Main Outcome Measures. The primary study outcome was change in self-esteem from baseline to the end of treatment. Secondary study measures were changes in other SEAR components, International Index of Erectile Function (IIEF) domains, percentage of intercourse attempts that were successful, and the response to a global efficacy question at the end of treatment. Results. Patients were well balanced for age and duration of ED (placebo = 149 and sildenafil = 151). Compared with placebo, sildenafil significantly improved self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction (P < 0.0001). The psychosocial measures of well-being assessed with the SEAR were positively correlated (range 0.60-0.86, P < 0.0001) with erectile function, the frequency of achieving erections that allowed satisfactory sexual intercourse, the percentage of successful sexual intercourse attempts, and global treatment efficacy. Conclusions. Significant improvements in self-esteem, confidence, sexual relationship satisfaction, and overall rela- tionship satisfaction after treatment of ED with sildenafil were consistent among countries. These data suggest a substantial cross-cultural improvement in well-being after successful treatment of ED with sildenafil. Althof S, O'Leary M, Cappelleri J, Hvidsten K, Stecher V, Glina S, King R, and Siegel R. Sildenafil citrate improves self-esteem, confidence, and relationships in men with erectile dysfunction: Results from an international, multi-center, double-blind, placebo-controlled trial. J Sex Med 2006;3:521-529.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sildenafil
Phosphodiesterase Inhibitors
Urology
Endocrinology, Diabetes and Metabolism
Sexual Behavior
Vasodilator Agents
Placebo-controlled study
Placebo
Drug Administration Schedule
Piperazines
Sildenafil Citrate
law.invention
chemistry.chemical_compound
Endocrinology
Randomized controlled trial
Double-Blind Method
Erectile Dysfunction
law
Surveys and Questionnaires
Medicine
Humans
Interpersonal Relations
Sulfones
Cross-Over Studies
Dose-Response Relationship, Drug
business.industry
Penile Erection
Middle Aged
medicine.disease
Crossover study
Self Concept
Psychiatry and Mental health
Sexual intercourse
Male Erectile Disorder
Erectile dysfunction
Treatment Outcome
Reproductive Medicine
chemistry
Patient Satisfaction
Purines
Physical therapy
business
Clinical psychology
Subjects
Details
- ISSN :
- 17436095
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The journal of sexual medicine
- Accession number :
- edsair.doi.dedup.....85fd5bbf7701c6eecc34d601793b6f0f