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Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications
- Source :
- Neuroscience bulletin. 31(4)
- Publication Year :
- 2015
-
Abstract
- Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA activity declines with age and is altered in neurodegenerative diseases. Its impairment leads to the accumulation of aggregated proteins, some of which may be directly tied to the pathogenic processes of neurodegenerative diseases. Its induction may accelerate the clearance of pathogenic proteins and promote cell survival, representing a potential therapeutic approach for the treatment of neurodegenerative diseases. In this review, we summarize the current findings on how CMA is involved in neurodegenerative diseases, especially in Parkinson’s disease.
- Subjects :
- Parkinson's disease
Physiology
Cellular homeostasis
Disease
Review
Biology
Chaperone-mediated autophagy
medicine
Autophagy
Animals
Humans
Microautophagy
health care economics and organizations
General Neuroscience
Neurodegeneration
Brain
Neurodegenerative Diseases
General Medicine
medicine.disease
humanities
Cell biology
Lysosomes
Neuroscience
Intracellular
Molecular Chaperones
Subjects
Details
- ISSN :
- 19958218
- Volume :
- 31
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neuroscience bulletin
- Accession number :
- edsair.doi.dedup.....85f66888b10d5537f44cc6f45a81f4f4