P5.05 INTERICTAL ARTERIAL WALL PARAMETERS IN WOMEN WITH MIGRAINE

Objective: According to data of epidemiological and clinical studies, migraine with aura (MA) is associated with cardiovascular disorders, and migraine without aura (M0) is linked to carotid artery dissection. The aim of this cross-sectional study was to evaluate and compare arterial wall parameters – intima-media thickness, distensibility and stiffness of common carotid artery (CCA), augmentation index and pulse wave velocity – in female patients with two types of migraine: MA and M0. Methods: Arterial wall structural and functional properties were measured using echo-tracking method (Art.Lab system) and applanation tonometry (SphygmoCor device) in 63 patients with M0 (age 35.32±7.83 years, migraine duration 17.25±8.44 years), 37 with MA (age 36.57±9.10 years, migraine duration 19.62±9.17 years) and 50 age-matched controls. Groups were compared using one-way ANOVA test. To explore the relationship between arterial wall parameters and type of migraine stepwise linear regression was applied. Results: MA patients had highest values of augmentation index (16.65±13.23 %), comparing with M0 patients (15.41±10.62 %) and controls (12.42±13.32 %). Distensibility of CCA was lowest in M0 patients (443.78±106.99 μm), comparing with MA patients (449.99±113.50 μm) and controls (465.78±112.36 μm). Differences of these parameters did not reach the level of significance. In regression analysis distensibility of CCA had inverse correlation with M0 (β=– 0.172, p=0.015). Other arterial wall parameters were similar between groups. Conclusions: Distensibility of common carotid artery is impaired in migraine without aura.