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Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma)
- Source :
- Expert Opinion on Investigational Drugs. 17:1703-1715
- Publication Year :
- 2008
- Publisher :
- Informa Healthcare, 2008.
-
Abstract
- New investigational agents and chemotherapy regimens including cyclophosphamide + topotecan, temozolomide + irinotecan, and anti-IGF-1R antibodies in Ewing's sarcoma (ES) and liposomal muramyltripeptide phosphatidylethanolamine (L-MTP-PE), aerosol therapy, and bone-specific agents in osteosarcoma (OS) may improve survival and/or quality of life on 'continuation' therapy.Review of investigational approaches and control paradigms for recurrent or metastatic primary bone tumors.Analyze temozolomide + irinotecan data and review in the context of other newer approaches including antiangiogenesis, anti-IGF-1R antibodies and bisphosphonates for ES. Review some current state-of-the-art approaches for OS including L-MTP-PE, anti-IGF-1R inhibition, aerosol therapies and bone specific agents.L-MTP-PE with chemotherapy in OS has been shown to improve survival; compassionate access is available for recurrence and/or metastases. Aerosol therapy (granulocyte-macrophage colony stimulating factor, cisplatin, gemcitabine) for lung metastases is a promising approach to reduce systemic toxicity. The bone-specific agents including denosumab (anti-receptor activator of NF-kappaB ligand antibody) and bisphosphonates may have benefit against giant cell tumor, ES and OS. Anti-IGF-1R antibody SCH717454 has preclinical activity in OS but best effectiveness will most likely be in combination with chemotherapy earlier in therapy. Both temozolomide + irinotecan and cyclophosphamide + topotecan combinations are very active in ES and are likely to be tested with anti-IGF-1R antibodies against ES.
- Subjects :
- Oncology
medicine.medical_specialty
Drug Evaluation, Preclinical
Antineoplastic Agents
Sarcoma, Ewing
Pharmacology
Internal medicine
medicine
Animals
Humans
Pharmacology (medical)
Neoplasm Metastasis
Osteosarcoma
Temozolomide
business.industry
Bone cancer
Ewing's sarcoma
General Medicine
medicine.disease
Radiography
Irinotecan
Denosumab
Topotecan
Immunotherapy
Sarcoma
business
medicine.drug
Subjects
Details
- ISSN :
- 17447658 and 13543784
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Investigational Drugs
- Accession number :
- edsair.doi.dedup.....85f0dc1b0da9e34ea613517cccad2743