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Optimal stereotactic body radiotherapy dosage for hepatocellular carcinoma: a multicenter study
- Source :
- Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021), Radiation Oncology (London, England)
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background The optimal dose and fractionation scheme of stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) remains unclear due to different tolerated liver volumes and degrees of cirrhosis. In this study, we aimed to verify the dose-survival relationship to optimize dose selection for treatment of HCC. Methods This multicenter retrospective study included 602 patients with HCC, treated with SBRT between January 2011 and March 2017. The SBRT dosage was classified into high dose, moderate dose, and low dose levels: SaRT (BED10 ≥ 100 Gy), SbRT (EQD2 > 74 Gy to BED10 2 Results The median tumor size was 5.6 cm (interquartile range [IQR] 1.1–21.0 cm). The median follow-up time was 50.0 months (IQR 6–100 months). High radiotherapy dose correlated with better outcomes. After classifying into the SaRT, SbRT, and ScRT groups, three notably different curves were obtained for long-term post-SBRT survival and intrahepatic control. On multivariate analysis, higher radiation dose was associated with improved OS, PFS, and intrahepatic control. Conclusions If tolerated by normal tissue, we recommend SaRT (BED10 ≥ 100 Gy) as a first-line ablative dose or SbRT (EQD2 ≥ 74 Gy) as a second-line radical dose. Otherwise, ScRT (EQD2
- Subjects :
- Adult
Male
medicine.medical_specialty
Survival rate
Carcinoma, Hepatocellular
Cirrhosis
Hepatocellular carcinoma
Stereotactic body radiotherapy
medicine.medical_treatment
Urology
R895-920
Radiosurgery
03 medical and health sciences
Medical physics. Medical radiology. Nuclear medicine
0302 clinical medicine
Interquartile range
medicine
Humans
Radiology, Nuclear Medicine and imaging
RC254-282
Retrospective Studies
business.industry
Radiotherapy dosage
Research
Radiotherapy Planning, Computer-Assisted
Liver Neoplasms
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Radiation therapy
Oncology
Multicenter study
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Radiotherapy, Intensity-Modulated
business
Subjects
Details
- Language :
- English
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology
- Accession number :
- edsair.doi.dedup.....85edded93565e0ed853013d75b2fdbe1