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Iodine Bonded with Milk Protein Inhibits Benign Prostatic Hyperplasia Development in Rats
- Source :
- Anti-cancer agents in medicinal chemistry. 19(13)
- Publication Year :
- 2019
-
Abstract
- Background: There is some evidence that Benign Prostatic Hyperplasia (BPH) may increase the risk of developing prostate cancer, so conducting research on effective BPH inhibitors is important. Objective: This research studied the inhibitory effect of Iodized Serum Milk Protein (ISMP) on BPH in rats. ISMP is a concentrate of lactic protein containing 2.2% iodine. Methods: Male Wistar rats, aged 18 months, were used. In the intact control group, sunflower oil was administered intragastrically by gavage. In 36 rats, BPH was induced by surgical castration, followed by subcutaneous injections of prolonged testosterone - omnadren, 25mg/kg every other day (7 administrations). One group of rats served as BPH-control. ISMP and finasteride (positive control), dissolved in sunflower oil, were administered to rats intragastrically daily at a dose of 200μg/kg and 5mg/kg, respectively, for 4 weeks starting immediately after castration. Results: ISMP inhibited the development of BPH in rats, significantly reducing the mass of the prostate and its parts (except for the anterior lobes) by 1.1-1.3 times and the prostatic index (the ratio of prostate weight to the body weight) - by 1.3-1.4 times. Finasteride inhibited the development of BPH, and its activity was higher (by 1.1-1.3 times) than in ISMP. : Histological analysis of the prostate showed fewer pronounced morphological hyperplasia signs in animals treated with ISMP or finasteride. Conclusion: The iodine-containing preparation ISMP has the ability to inhibit the development of BPH in rats although its activity is somewhat lower than that of finasteride.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
food.ingredient
030232 urology & nephrology
Urology
Prostatic Hyperplasia
chemistry.chemical_element
Iodine
03 medical and health sciences
Prostate cancer
chemistry.chemical_compound
0302 clinical medicine
food
Prostate
medicine
Animals
Rats, Wistar
Testosterone
Pharmacology
business.industry
Sunflower oil
Finasteride
Androgen Antagonists
Hyperplasia
medicine.disease
Milk Proteins
Rats
medicine.anatomical_structure
Castration
chemistry
030220 oncology & carcinogenesis
Molecular Medicine
business
Subjects
Details
- ISSN :
- 18755992
- Volume :
- 19
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Anti-cancer agents in medicinal chemistry
- Accession number :
- edsair.doi.dedup.....85db2fc15633da3b7e6e18c0afc1cf78