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Primary human herpesvirus 8 infection in immunocompetent children
- Source :
- Scopus-Elsevier
- Publication Year :
- 2002
-
Abstract
- ContextHuman herpesvirus 8 (HHV-8) infection causes Kaposi sarcoma and lymphoproliferative disorders in immunosuppressed adults. Its manifestations in immunocompetent hosts are unknown.ObjectivesTo determine whether HHV-8 primary infection is symptomatic in immunocompetent children and to identify the epidemiological and virological correlates of HHV-8 infection.Design and SettingProspective cohort study conducted in the pediatric emergency department of a hospital in Alexandria, Egypt, between December 1, 1999, and April 30, 2000.PatientsEighty-six children aged 1 to 4 years who were evaluated for a febrile syndrome of undetermined origin.Main Outcome MeasuresSerological assay and polymerase chain reaction of blood and saliva samples for HHV-8. Information on potential risk factors for HHV-8 infection was also collected.ResultsThirty-six children (41.9%) were seropositive; HHV-8 DNA sequences were detected in 14 (38.9%) of these 36 children (detected in saliva in 11 of 14). Significant associations were found between HHV-8 infection and close contact with at least 2 other children in the community (36 of 63 vs 6 of 23 for
- Subjects :
- Male
medicine.medical_specialty
Settore MED/17 - Malattie Infettive
media_common.quotation_subject
Fluorescent Antibody Technique
Antibodies, Viral
Fever of Unknown Origin
Polymerase Chain Reaction
Serology
Cohort Studies
Risk Factors
Internal medicine
Epidemiology
Maculopapular rash
medicine
Humans
Fever of unknown origin
Saliva
media_common
Skin Diseases, Vesiculobullous
business.industry
Convalescence
virus diseases
Infant
General Medicine
Odds ratio
Herpesviridae Infections
medicine.disease
Rash
Child, Preschool
Immunology
DNA, Viral
Herpesvirus 8, Human
Female
medicine.symptom
business
Immunocompetence
Cohort study
Subjects
Details
- ISSN :
- 00987484
- Volume :
- 287
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- JAMA
- Accession number :
- edsair.doi.dedup.....85c9b3fe83e6fe97f086de70e98e136d