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5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:5067-5070
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- 5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
- Subjects :
- Male
medicine.drug_class
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Stereoisomerism
In Vitro Techniques
Biochemistry
Chemical synthesis
Structure-Activity Relationship
chemistry.chemical_compound
Cricetinae
Drug Discovery
medicine
Organic chemistry
Animals
Humans
Structure–activity relationship
Molecular Biology
Chemistry
Organic Chemistry
Biological activity
General Medicine
Amides
Cyclic P-Oxides
Carrier protein
Microsome
Molecular Medicine
Benzimidazoles
Piperidine
Carrier Proteins
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....85b1bcb5468af7eea694a534e738ef69