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Hepatitis C virus infection as a risk factor for Parkinson disease
- Source :
- Neurology. 86:840-846
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Objective: To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD). Methods: This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The crude HRs for developing PD was 0.66 (95% CI = 0.55–0.80) for HBV infection, 2.50 (95% CI = 2.07–3.02) for HCV infection, and 1.28 (95% CI = 0.88–1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR = 1.29, 95% CI = 1.06–1.56). Conclusions: We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Hepatitis C virus
Taiwan
Comorbidity
medicine.disease_cause
Risk Assessment
Sensitivity and Specificity
Cohort Studies
03 medical and health sciences
Age Distribution
0302 clinical medicine
Internal medicine
medicine
Humans
Sex Distribution
Risk factor
Aged
Hepatitis B virus
business.industry
Incidence
Reproducibility of Results
virus diseases
Parkinson Disease
Hepatitis C
Middle Aged
medicine.disease
digestive system diseases
Causality
030104 developmental biology
Immunology
Cohort
Coinfection
Female
Neurology (clinical)
Viral hepatitis
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....85a649a285e6c7315f0ae13eaa5149c5